Scientist at the Clear Synth Research Centre in India, Dr Merugu Srinivas Reddy, graduated from UKZN with a PhD in Pharmaceutical Chemistry for his study on modern medicine and the emergence of antimicrobial resistance.
The study focused on Mycobacterium tuberculosis, which is a major health challenge in Africa and Asia. Reddy successfully synthesised 84 novel compounds to inhibit bacterial DNA-gyrase. Bacterial DNA gyrases are the usual target of quinolone drugs, effectively killing bacteria by inhibiting DNA replication.
The findings thus point to a new pathway to control drug-resistant strains of Mycobacterium tuberculosis.
Reddy completed his masters in Chemistry at Swami Ramanand Teerth Marathwada University in India and went on to work as a research chemist in the pharmaceutical industry. He has been involved in the design and synthesis of several labelled (CD3, 13CD3, 13C, 15N) drugs and various drug impurities.
He acknowledged the support and guidance of his supervisor, Professor Rajshekar Karpoormath and also thanked his colleagues, his wife Madhuri and his family for their support.
In his spare time, Reddy enjoys spending time with family and indulging in cooking and reading.
Words: Mandisa Shozi